Dr. Kristian M. Hargadon ’01 Publishes Major Review Article on Dendritic Cells

Elliott Assistant Professor of Biology, Dr. Kristian M. Hargadon ’01, recently had a major review article published in the journal International Reviews of Immunology.  The article, entitled “Murine and Human Model Systems for the Study of Dendritic Cell Immunobiology,” highlights the tools and strategies employed by immunologists to study dendritic cells, a key regulatory cell type of the immune system that is critical for both the induction of immune activation and tolerance.  These cells play major roles in immunity to pathogens, transplant acceptance/rejection, autoimmunity, and anti-tumor immunity, and their impact on the field was the basis for the 2011 Nobel Prize in Physiology or Medicine that was awarded to three investigators who discovered and offered in-depth functional characterization of these cells.  In addition to emphasizing methodologies that have enabled experimental analyses of dendritic cells, Dr. Hargadon’s review also offers insights as to how the model systems currently in use to study these cells might be manipulated going forward to gain better a better understanding of the development and function of dendritic cells.  International Reviews of Immunology is published by Informa Healthcare and is one of the leading review journals in the field of immunology.  Dr. Hargadon’s research program focuses on the modification of dendritic cell function by tumors and how tumor-altered dendritic cells impact the quality of anti-tumor T cell responses.

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