The current issue of the research journal Cellular Immunology features an article authored by Assistant Professor of Biology Dr. Kristian Hargadon and undergraduates Osric Forrest ’12 and Pranay Reddy ’11.  The article entitled “Suppression of the Maturation and Activation of the Dendritic Cell Line DC2.4 by Melanoma-derived Factors” describes work conducted by Dr. Hargadon and his students over the past two years.  This study demonstrates that melanoma tumors are capable of suppressing dendritic cells, an immune cell that is critical for the induction of anti-tumor immune responses.  Importantly, Dr. Hargadon and his students demonstrated that the extent to which dendritic cells are suppressed by melanomas is dependent on how agressive the particular tumor is.  These findings therefore suggest that the interactions that take place between melanoma tumor cells and dendritic cells may ultimately dictate the success of the overall immune response to the tumor.  Dr. Hargadon and other undergraduate students working in his lab are continuing to investigating how melanomas suppress dendritic cell functionality and how such melanoma-altered dendritic cells shape the response of other anti-tumor immune cells.  It is hoped that these studies will improve our understanding of tumor immune escape and identify strategies for interfering with tumor immune suppression and improving the quality of anti-tumor immune responses.